Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 6/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 4/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3357832 | 0.92 | ZAP70 (0.42) | ZAP70SOS1BTKSYKOPRL1 | |
| SCHEMBL3359250 | 0.90 | ZAP70 (0.53) | ZAP70SYKBRD4TBK1 | |
| SCHEMBL3359436 | 0.90 | ZAP70 (0.48) | ZAP70SYKKCNH2TBK1 | |
| SCHEMBL3358576 | 0.90 | ZAP70 (0.40) | ZAP70CREBBPSOS1BTKSYK | |
| SCHEMBL3358701 | 0.89 | ZAP70 (0.47) | ZAP70SYKTBK1 | |
| SCHEMBL3360152 | 0.89 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL3359784 | 0.88 | ZAP70 (0.51) | ZAP70SOS1SYK | |
| SCHEMBL3358232 | 0.85 | ZAP70 (0.46) | ZAP70SYKTBK1 | |
| SCHEMBL3360670 | 0.84 | ZAP70 (0.48) | ZAP70SYK | |
| SCHEMBL3362565 | 0.84 | ZAP70 (0.40) | ZAP70SOS1BTKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |