Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.64 |
| ▸ | SYK | P43405 | 6/20 | 0.34 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359250 | 0.92 | ZAP70 (0.53) | ZAP70SYKWEE1ABL1PDGFRB | |
| SCHEMBL3359784 | 0.90 | ZAP70 (0.51) | ZAP70SYKWEE1ABL1PDGFRB | |
| SCHEMBL3360946 | 0.89 | ZAP70 (0.51) | ZAP70SYKWEE1 | |
| SCHEMBL3359512 | 0.89 | ZAP70 (0.51) | ZAP70SYK | |
| SCHEMBL3358634 | 0.88 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3360670 | 0.86 | ZAP70 (0.48) | ZAP70SYKWEE1 | |
| SCHEMBL3359436 | 0.86 | ZAP70 (0.48) | ZAP70SYK | |
| SCHEMBL3358701 | 0.84 | ZAP70 (0.47) | ZAP70SYK | |
| SCHEMBL3358232 | 0.83 | ZAP70 (0.46) | ZAP70SYK | |
| SCHEMBL3361858 | 0.83 | ZAP70 (0.47) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |