Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSA | P10619 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358300 | 0.89 | HPGD (0.50) | HPGDKCNA5MAPTPOLBALDH1A1 | |
| SCHEMBL2347309 | 0.87 | HPGD (0.57) | HPGDTACR1KCNA5MAPTPOLB | |
| SCHEMBL24661003 | 0.83 | KCNA5 (0.52) | CTSAHPGDTACR1KCNA5MAPT | |
| SCHEMBL6306108 | 0.83 | MTNR1A (0.63) | CASRTACR1MTNR1AMTNR1B | |
| SCHEMBL9444890 | 0.79 | SLC6A3 (0.48) | HPGDALDH1A1 | |
| SCHEMBL29174146 | 0.78 | MAPT (0.50) | HPGDTACR1KCNA5MAPTPOLB | |
| SCHEMBL1429119 | 0.78 | KMT2A (0.60) | HPGDCASRTACR1ALDH1A1MEN1 | |
| SCHEMBL3356282 | 0.77 | MAPT (0.46) | HPGDKCNA5TACR3MAPTPOLB | |
| SCHEMBL29174151 | 0.76 | MEN1 (0.49) | HPGDTACR1KCNA5MEN1KMT2A | |
| SCHEMBL28677834 | 0.75 | KCNA5 (0.52) | HPGDKCNA5MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687482-B2 | Bisphosphonate compounds and methods | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-03-30 | — | — | US | disclosed |