Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 10/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354572 | 0.90 | MEN1 (0.51) | ROCK2ABCG2ABCB1MEN1KMT2A | |
| SCHEMBL3354054 | 0.89 | ABCG2 (0.49) | ROCK2ABCG2ABCB1MEN1KMT2A | |
| SCHEMBL3359330 | 0.87 | ROCK2 (0.43) | ROCK2ABCG2ABCB1MEN1KMT2A | |
| SCHEMBL3388455 | 0.85 | ROCK2 (0.47) | ROCK2 | |
| SCHEMBL3387897 | 0.85 | ROCK2 (0.46) | ROCK2ABCG2KDM4EMAPTPDE5A | |
| SCHEMBL16404477 | 0.72 | PDE5A (0.66) | ABCG2ABCB1MEN1KMT2AABCC1 | |
| SCHEMBL3356239 | 0.70 | ROCK2 (0.56) | ROCK2 | |
| SCHEMBL3359796 | 0.69 | ROCK2 (0.51) | ROCK2 | |
| SCHEMBL3384565 | 0.68 | ROCK2 (0.62) | ROCK2MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3387854 | 0.67 | ROCK2 (0.60) | ROCK2MEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056758-A1 | QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-05-20 | — | — | WO | disclosed |