Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361696 | 0.90 | SYK (0.43) | SYKABL1BCREGFRIGF1R | |
| SCHEMBL3359073 | 0.88 | TNIK (0.42) | SYKABL1BCREGFRIGF1R | |
| SCHEMBL3359920 | 0.83 | IGF1R (0.39) | SYKABL1BCREGFRIGF1R | |
| SCHEMBL1158304 | 0.79 | ZAP70 (0.44) | SYKABL1KDRZAP70 | |
| SCHEMBL3362294 | 0.79 | BCHE (0.45) | SYKEGFRCDK1KDR | |
| SCHEMBL3359957 | 0.78 | SYK (0.43) | SYKABL1BCREGFRCDK1 | |
| SCHEMBL1044291 | 0.77 | ZAP70 (0.61) | SYKZAP70 | |
| SCHEMBL3362166 | 0.77 | ZAP70 (0.49) | SYKEGFRZAP70 | |
| SCHEMBL1159575 | 0.76 | ZAP70 (0.49) | SYKZAP70 | |
| SCHEMBL3362036 | 0.75 | MAP3K11 (0.37) | SYKEGFRKDRZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |