Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 6/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358634 | 0.85 | ZAP70 (0.49) | ZAP70BTK | |
| SCHEMBL3360737 | 0.85 | ZAP70 (0.46) | ZAP70BTKSYK | |
| SCHEMBL3362166 | 0.83 | ZAP70 (0.49) | ZAP70BTKSYK | |
| SCHEMBL3362708 | 0.82 | ZAP70 (0.49) | ZAP70SYK | |
| SCHEMBL3358601 | 0.82 | ZAP70 (0.49) | ZAP70SYK | |
| SCHEMBL1158304 | 0.81 | ZAP70 (0.44) | ZAP70SYK | |
| SCHEMBL3362296 | 0.81 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3359250 | 0.81 | ZAP70 (0.53) | ZAP70SYK | |
| SCHEMBL3363125 | 0.80 | ZAP70 (0.49) | ZAP70 | |
| SCHEMBL3362467 | 0.80 | ZAP70 (0.49) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459556-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | claimed |