Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | AVPR1B | P47901 | 7/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361696 | 0.86 | SYK (0.43) | IGF1REGFRSYKAVPR1BZAP70 | |
| SCHEMBL3358542 | 0.83 | SYK (0.42) | IGF1REGFRSYKAVPR1BZAP70 | |
| SCHEMBL3359073 | 0.82 | TNIK (0.42) | IGF1REGFRSYKAVPR1BZAP70 | |
| SCHEMBL3359787 | 0.79 | SLC18A3 (0.36) | SYKZAP70 | |
| SCHEMBL3361210 | 0.79 | SRC (0.42) | EGFRSYKKDR | |
| SCHEMBL3361998 | 0.78 | ZAP70 (0.42) | EGFRZAP70 | |
| SCHEMBL3362321 | 0.78 | TGFBR1 (0.35) | IGF1REGFRZAP70 | |
| SCHEMBL1047312 | 0.78 | ZAP70 (0.60) | IGF1RSYKZAP70 | |
| SCHEMBL3360034 | 0.77 | ZAP70 (0.45) | EGFRZAP70CAMK2D | |
| SCHEMBL3358985 | 0.76 | ZAP70 (0.43) | IGF1REGFRZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |