Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 3/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358542 | 0.90 | SYK (0.42) | SYKZAP70EGFRABL1BCR | |
| SCHEMBL3359920 | 0.86 | IGF1R (0.39) | SYKZAP70EGFRABL1BCR | |
| SCHEMBL3359073 | 0.86 | TNIK (0.42) | SYKZAP70EGFRABL1BCR | |
| SCHEMBL1047753 | 0.76 | ZAP70 (0.74) | SYKZAP70JAK2 | |
| SCHEMBL3359957 | 0.74 | SYK (0.43) | SYKZAP70JAK2EGFRABL1 | |
| SCHEMBL3360194 | 0.74 | SRC (0.46) | SYKEGFR | |
| SCHEMBL3361210 | 0.73 | SRC (0.42) | SYKJAK2EGFRKDR | |
| SCHEMBL3362036 | 0.73 | MAP3K11 (0.37) | SYKZAP70EGFRKDR | |
| SCHEMBL3359445 | 0.73 | ZAP70 (0.46) | SYKZAP70JAK2MAPT | |
| SCHEMBL3360211 | 0.73 | JAK2 (0.41) | SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |