Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359270 | 0.88 | SYK (0.41) | SYKKDRZAP70JAK3BTK | |
| SCHEMBL3360902 | 0.87 | SYK (0.39) | SYKHSD11B1KDRZAP70JAK3 | |
| SCHEMBL3362622 | 0.87 | SYK (0.37) | SYKACP1JAK3BTKEGFR | |
| SCHEMBL3362595 | 0.86 | ZAP70 (0.48) | SYKACP1KDRZAP70JAK3 | |
| SCHEMBL3360737 | 0.85 | ZAP70 (0.46) | SYKZAP70JAK3BTKCYP11B1 | |
| SCHEMBL3360354 | 0.84 | MAP4K1 (0.41) | SYKKDRZAP70JAK3BTK | |
| SCHEMBL3362971 | 0.82 | JAK2 (0.38) | ZAP70JAK3BTKEGFRLCK | |
| SCHEMBL3359025 | 0.82 | SYK (0.42) | SYKZAP70JAK3JAK2PTK2 | |
| SCHEMBL3360029 | 0.81 | PTK2 (0.42) | SYKZAP70JAK3JAK2PTK2 | |
| SCHEMBL3360647 | 0.81 | ZAP70 (0.43) | SYKZAP70JAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |