Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358985 | 0.88 | ZAP70 (0.43) | ZAP70EGFRBTKJAK2AURKA | |
| SCHEMBL3358328 | 0.86 | ZAP70 (0.42) | ZAP70EGFRBTKAURKAMAPT | |
| SCHEMBL3358598 | 0.83 | SYK (0.43) | ZAP70EGFRJAK2AURKAMAPT | |
| SCHEMBL3359647 | 0.82 | MAPT (0.43) | ZAP70AURKAMAPTMAPK1TP53 | |
| SCHEMBL3358312 | 0.82 | MAPT (0.46) | ZAP70EGFRJAK2AURKAMAPT | |
| SCHEMBL3358947 | 0.80 | CYP2C19 (0.40) | ZAP70EGFRJAK2AURKAMAPT | |
| SCHEMBL3358758 | 0.80 | SYK (0.44) | ZAP70JAK2AURKAMAPTMAPK1 | |
| SCHEMBL3359445 | 0.80 | ZAP70 (0.46) | ZAP70BTKJAK2AURKAMAPT | |
| SCHEMBL1159612 | 0.80 | ZAP70 (0.40) | ZAP70EGFRBTKMAPTMAPK1 | |
| SCHEMBL3362709 | 0.80 | SYK (0.45) | ZAP70BTKAURKAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |