Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 19/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | BUB1B | O60566 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | NPM1 | P06748 | 1/20 | 0.40 |
| ▸ | FES | P07332 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359057 | 0.81 | SYK (0.41) | ALKCDK7CDK9INSRKCNH2 | |
| SCHEMBL3360357 | 0.80 | ALK (0.39) | ALKINSRKCNH2JAK2EGFR | |
| SCHEMBL1048072 | 0.80 | ALK (0.58) | ALKCDK7CDK9INSRKCNH2 | |
| SCHEMBL3357802 | 0.78 | ALK (0.39) | ALKCDK7CDK9INSRKCNH2 | |
| SCHEMBL3359688 | 0.77 | CHEK1 (0.40) | ALKJAK2EGFRABCB1JAK3 | |
| SCHEMBL3360058 | 0.74 | JAK3 (0.40) | ALKJAK2ZAP70SYKJAK3 | |
| SCHEMBL3362350 | 0.74 | ALK (0.38) | ALKCDK9INSRJAK2EGFR | |
| SCHEMBL3362356 | 0.74 | BTK (0.38) | ALKJAK2IGF1RJAK1ZAP70 | |
| SCHEMBL3362286 | 0.72 | ALK (0.36) | ALKJAK2ROCK2EGFRIGF1R | |
| SCHEMBL3359794 | 0.72 | JAK2 (0.38) | ALKJAK2ZAP70SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |