Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3360759 | 0.87 | SYK (0.36) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL3359025 | 0.86 | SYK (0.42) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL3360029 | 0.85 | PTK2 (0.42) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL3362704 | 0.83 | ZAP70 (0.40) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL3362948 | 0.82 | JAK3 (0.36) | PTK2JAK3JAK2SYKEGFR | |
| SCHEMBL3360308 | 0.81 | SYK (0.44) | ALKJAK3SYKEGFRLCK | |
| SCHEMBL3362622 | 0.80 | SYK (0.37) | PTK2JAK3JAK2SYKEGFR | |
| SCHEMBL3361412 | 0.79 | JAK3 (0.41) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL27806032 | 0.79 | ALK (0.39) | ALKPTK2JAK3JAK2SYK | |
| SCHEMBL3361735 | 0.79 | SYK (0.40) | PTK2JAK3JAK2SYKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |