Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 4/20 | 0.36 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359627 | 0.90 | MAP4K1 (0.42) | EGFRBTKJAK2PTK2MAP4K1 | |
| SCHEMBL3361735 | 0.87 | SYK (0.40) | SYKEGFRBTKJAK2PTK2 | |
| SCHEMBL3360902 | 0.83 | SYK (0.39) | SYKEGFRBTKJAK2PTK2 | |
| SCHEMBL3362595 | 0.83 | ZAP70 (0.48) | SYKEGFRBTKJAK2PTK2 | |
| SCHEMBL3360354 | 0.83 | MAP4K1 (0.41) | SYKEGFRBTKJAK3MAP4K1 | |
| SCHEMBL3359270 | 0.80 | SYK (0.41) | SYKEGFRBTKJAK3LCK | |
| SCHEMBL3362901 | 0.80 | MAP4K1 (0.44) | EGFRCCNT1CDK9MAP4K1 | |
| SCHEMBL3359173 | 0.80 | ALK (0.39) | SYKEGFRBTKJAK2PTK2 | |
| SCHEMBL1047402 | 0.79 | ZAP70 (0.55) | SYKEGFRCCNT1CDK9 | |
| SCHEMBL3358417 | 0.79 | JAK2 (0.41) | EGFRBTKJAK2PTK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |