Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 5/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359650 | 0.86 | SYK (0.39) | JAK3JAK2JAK1TYK2HTT | |
| SCHEMBL3359096 | 0.84 | JAK3 (0.41) | JAK3JAK2JAK1TYK2HTT | |
| SCHEMBL3360938 | 0.82 | ZAP70 (0.49) | ZAP70JAK3JAK2JAK1TYK2 | |
| SCHEMBL3356910 | 0.81 | MTOR (0.42) | JAK3JAK2JAK1TYK2EGFR | |
| SCHEMBL3361956 | 0.81 | EGFR (0.39) | JAK3JAK2JAK1TYK2HTT | |
| SCHEMBL3359372 | 0.80 | TGFBR1 (0.40) | JAK3JAK2JAK1TYK2HTT | |
| SCHEMBL1044950 | 0.79 | ZAP70 (0.79) | ZAP70JAK3JAK2JAK1TYK2 | |
| SCHEMBL27826829 | 0.78 | ZAP70 (0.47) | ZAP70JAK3JAK2JAK1TYK2 | |
| SCHEMBL3358704 | 0.78 | PIK3CA (0.44) | ZAP70SYKMAPK9MAPK10 | |
| SCHEMBL3362037 | 0.76 | PIK3CA (0.43) | ZAP70JAK3JAK1SYKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |