Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | BCL6 | P41182 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362890 | 0.90 | ZAP70 (0.39) | EGFRBTKP2RX3CCNT1CDK9 | |
| SCHEMBL3359607 | 0.89 | KDR (0.41) | JAK3JAK2SYK | |
| SCHEMBL3356910 | 0.85 | MTOR (0.42) | EGFRBTKP2RX3CCNT1CDK9 | |
| SCHEMBL3359372 | 0.84 | TGFBR1 (0.40) | EGFRBTKHTTP2RX3MTOR | |
| SCHEMBL3359096 | 0.82 | JAK3 (0.41) | EGFRBTKHTTP2RX3MTOR | |
| SCHEMBL3359217 | 0.81 | ZAP70 (0.49) | EGFRBTKHTTP2RX3CCNT1 | |
| SCHEMBL3359650 | 0.80 | SYK (0.39) | EGFRBTKHTTP2RX3MTOR | |
| SCHEMBL1048402 | 0.79 | ZAP70 (0.52) | HTTP2RX3CCNT1CDK9CCNA2 | |
| SCHEMBL27826631 | 0.79 | JAK3 (0.39) | EGFRBTKHTTP2RX3CCNT1 | |
| SCHEMBL3362516 | 0.76 | ZAP70 (0.47) | EGFRBTKP2RX3CDK2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |