Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362516 | 0.90 | ZAP70 (0.47) | MTORP2RX3PIK3CGPIK3CDPIK3CA | |
| SCHEMBL3359096 | 0.89 | JAK3 (0.41) | MTORP2RX3SYKCSF1RCDK4 | |
| SCHEMBL3362714 | 0.89 | ABL1 (0.45) | MTORPIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3361956 | 0.85 | EGFR (0.39) | MTORP2RX3SYKBCL6CSF1R | |
| SCHEMBL3359372 | 0.84 | TGFBR1 (0.40) | MTORP2RX3SYKBCL6JAK3 | |
| SCHEMBL3358704 | 0.82 | PIK3CA (0.44) | MTORPIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL3362713 | 0.81 | ZAP70 (0.56) | MTORP2RX3PIK3CGPIK3CDPIK3CA | |
| SCHEMBL3361838 | 0.81 | ZAP70 (0.40) | MTORP2RX3PIK3CGPIK3CDPIK3CA | |
| SCHEMBL3359217 | 0.81 | ZAP70 (0.49) | P2RX3SYKCSF1RCDK4CDK6 | |
| SCHEMBL3359073 | 0.81 | TNIK (0.42) | SYKCSF1RTNIKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |