Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 4/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358792 | 0.91 | ZAP70 (0.42) | ZAP70TGFBR1JAK2TBK1EGFR | |
| SCHEMBL3362284 | 0.87 | ZAP70 (0.39) | ZAP70TGFBR1ERBB2JAK2TBK1 | |
| SCHEMBL3358711 | 0.85 | PDE10A (0.36) | ZAP70SOS1BTKPDE10A | |
| SCHEMBL3359512 | 0.84 | ZAP70 (0.51) | ZAP70SOS1BTKTBK1 | |
| SCHEMBL3358576 | 0.83 | ZAP70 (0.40) | ZAP70SOS1BTKPDE10A | |
| SCHEMBL3357832 | 0.83 | ZAP70 (0.42) | ZAP70SOS1BTK | |
| SCHEMBL1158133 | 0.83 | ZAP70 (0.48) | ZAP70SOS1ERBB2JAK2TBK1 | |
| SCHEMBL3359006 | 0.81 | BTK (0.43) | ZAP70SOS1BTKJAK2EGFR | |
| SCHEMBL1158541 | 0.80 | ZAP70 (0.49) | ZAP70TGFBR1JAK2TBK1 | |
| SCHEMBL1049107 | 0.80 | ZAP70 (0.63) | ZAP70JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |