Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.48 |
| ▸ | SYK | P43405 | 5/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158541 | 0.92 | ZAP70 (0.49) | ZAP70SYKTGFBR1WEE1 | |
| SCHEMBL3359058 | 0.90 | ZAP70 (0.42) | ZAP70SYKEGFR | |
| SCHEMBL1159549 | 0.85 | ZAP70 (0.40) | ZAP70SYKWEE1 | |
| SCHEMBL1158133 | 0.85 | ZAP70 (0.48) | ZAP70SYK | |
| SCHEMBL3362965 | 0.85 | ZAP70 (0.55) | ZAP70SYKWEE1 | |
| SCHEMBL3359028 | 0.83 | ZAP70 (0.41) | ZAP70SYKEGFR | |
| SCHEMBL3362284 | 0.83 | ZAP70 (0.39) | ZAP70SYKTGFBR1WEE1 | |
| SCHEMBL1049079 | 0.81 | ZAP70 (0.73) | ZAP70SYKEGFR | |
| SCHEMBL3358792 | 0.81 | ZAP70 (0.42) | ZAP70SYKEGFRTGFBR1WEE1 | |
| SCHEMBL3359856 | 0.80 | ZAP70 (0.40) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |