Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.40 |
| ▸ | SYK | P43405 | 11/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | CCR2 | P41597 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359648 | 0.85 | ZAP70 (0.48) | ZAP70SYKWEE1 | |
| SCHEMBL3358316 | 0.84 | ZAP70 (0.39) | ZAP70SYKCCR2 | |
| SCHEMBL3361273 | 0.82 | SYK (0.43) | ZAP70SYKWEE1JAK2 | |
| SCHEMBL3360670 | 0.82 | ZAP70 (0.48) | ZAP70SYKWEE1JAK2 | |
| SCHEMBL3359250 | 0.81 | ZAP70 (0.53) | ZAP70SYKWEE1JAK2 | |
| SCHEMBL1158070 | 0.80 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL3359219 | 0.80 | ZAP70 (0.41) | ZAP70SYK | |
| SCHEMBL3357832 | 0.80 | ZAP70 (0.42) | ZAP70SYKWEE1 | |
| SCHEMBL3360946 | 0.79 | ZAP70 (0.51) | ZAP70SYKWEE1 | |
| SCHEMBL1158376 | 0.79 | SYK (0.36) | ZAP70SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459556-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | claimed |