Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.36 |
| ▸ | INSR | P06213 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.32 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358792 | 0.91 | ZAP70 (0.42) | ZAP70TGFBR1BRD4SYKWEE1 | |
| SCHEMBL3358208 | 0.90 | TLR9 (0.40) | ZAP70TGFBR1TLR9BRD4ATAD2 | |
| SCHEMBL3362565 | 0.87 | ZAP70 (0.40) | ZAP70TGFBR1ERBB2JAK2TBK1 | |
| SCHEMBL3362099 | 0.85 | ZAP70 (0.45) | ZAP70ALKINSRTLR9BRD4 | |
| SCHEMBL1158541 | 0.84 | ZAP70 (0.49) | ZAP70TGFBR1ALKINSRBRD4 | |
| SCHEMBL3359648 | 0.83 | ZAP70 (0.48) | ZAP70TGFBR1SYKWEE1 | |
| SCHEMBL1158376 | 0.81 | SYK (0.36) | ZAP70ALKINSRBRD4ATAD2 | |
| SCHEMBL3361810 | 0.81 | TLR9 (0.39) | ZAP70TGFBR1TLR9HTR1ADRD2 | |
| SCHEMBL1045873 | 0.80 | ZAP70 (0.62) | ZAP70TGFBR1ALKTLR9BRD4 | |
| SCHEMBL3359856 | 0.80 | ZAP70 (0.40) | ZAP70ALKINSRBRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |