Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362284 | 0.91 | ZAP70 (0.39) | ZAP70WEE1TGFBR1SYKTBK1 | |
| SCHEMBL3362565 | 0.91 | ZAP70 (0.40) | ZAP70TGFBR1TBK1JAK2EGFR | |
| SCHEMBL3359250 | 0.83 | ZAP70 (0.53) | ZAP70WEE1SYKTBK1JAK2 | |
| SCHEMBL3361273 | 0.82 | SYK (0.43) | ZAP70WEE1SYKTBK1JAK2 | |
| SCHEMBL1158541 | 0.82 | ZAP70 (0.49) | ZAP70WEE1TGFBR1SYKTBK1 | |
| SCHEMBL3359648 | 0.81 | ZAP70 (0.48) | ZAP70WEE1TGFBR1SYKEGFR | |
| SCHEMBL3358208 | 0.81 | TLR9 (0.40) | ZAP70TGFBR1JAK2EGFRBRD4 | |
| SCHEMBL3362965 | 0.80 | ZAP70 (0.55) | ZAP70WEE1EHMT2SYK | |
| SCHEMBL3361998 | 0.80 | ZAP70 (0.42) | ZAP70WEE1JAK2EGFRBRD4 | |
| SCHEMBL1158133 | 0.80 | ZAP70 (0.48) | ZAP70SYKTBK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |