Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 3/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359028 | 0.91 | ZAP70 (0.41) | TLR9EGFRZAP70HRH3MCHR1 | |
| SCHEMBL3358208 | 0.90 | TLR9 (0.40) | TLR9EGFRZAP70HRH3HTR1A | |
| SCHEMBL3359794 | 0.84 | JAK2 (0.38) | ZAP70JAK2JAK3PTK2BTK | |
| SCHEMBL3359058 | 0.83 | ZAP70 (0.42) | TLR9EGFRZAP70HRH3CCR2 | |
| SCHEMBL3362321 | 0.83 | TGFBR1 (0.35) | EGFRZAP70HRH3MCHR1HTR1A | |
| SCHEMBL1049336 | 0.81 | ZAP70 (0.56) | TLR9EGFRZAP70 | |
| SCHEMBL3362284 | 0.81 | ZAP70 (0.39) | TLR9ZAP70HTR1ADRD2DRD4 | |
| SCHEMBL3359787 | 0.80 | SLC18A3 (0.36) | TLR9ZAP70HTR1ADRD2DRD4 | |
| SCHEMBL3358792 | 0.78 | ZAP70 (0.42) | EGFRZAP70TGFBR1JAK2 | |
| SCHEMBL3361998 | 0.78 | ZAP70 (0.42) | EGFRZAP70MAP4K1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |