SCHEMBL3360786

SCHEMBL3360786

O=c1[nH]c2cc(F)cc(Cl)c2cc1O

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
DAO P14920 11/20 0.58
DDO Q99489 6/20 0.51
SRC P12931 1/20 0.46
GRIN2D O15399 1/20 0.41
GRIN3B O60391 1/20 0.41
GRIN1 Q05586 1/20 0.41
GRIN2A Q12879 1/20 0.41
GRIN2B Q13224 1/20 0.41
GRIN2C Q14957 1/20 0.41
GRIN3A Q8TCU5 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3359995 0.79 DAO (0.58) DAODDOSRCGRIN2DGRIN3B
SCHEMBL3431869 0.77 DAO (0.49) DAODDOSRC
SCHEMBL3363146 0.77 DAO (0.60) DAODDOSRCGRIN2DGRIN3B
SCHEMBL8873379 0.76 GRIN1 (0.51) DAOSRCGRIN2DGRIN3BGRIN1
SCHEMBL3422876 0.76 DAO (0.54) DAODDOSRCGRIN2DGRIN3B
SCHEMBL3395093 0.75 DAO (0.67) DAODDOSRCGRIN2DGRIN3B
SCHEMBL8873562 0.74 DAO (0.51) DAODDOSRCGRIN2DGRIN3B
SCHEMBL16767849 0.74 DAO (1.00) DAODDOGRIN2DGRIN3BGRIN1
SCHEMBL9007832 0.72 DAO (0.65) DAODDO
SCHEMBL3359927 0.72 GRIN2D (0.45) DAODDOGRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010058314-A1 HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF PFIZER INC. (US) 2010-05-27 WO disclosed