Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361998 | 0.90 | ZAP70 (0.42) | BRD4BTKJAK3EGFRZAP70 | |
| SCHEMBL3361735 | 0.87 | SYK (0.40) | SYKBTKJAK3EGFRLCK | |
| SCHEMBL3359006 | 0.87 | BTK (0.43) | SYKBRD4BTKJAK3EGFR | |
| SCHEMBL3362356 | 0.85 | BTK (0.38) | SYKBRD4BTKJAK3ZAP70 | |
| SCHEMBL3359787 | 0.85 | SLC18A3 (0.36) | SYKBRD4BTKZAP70HTR1A | |
| SCHEMBL3362321 | 0.84 | TGFBR1 (0.35) | BRD4BTKEGFRZAP70TYK2 | |
| SCHEMBL3362622 | 0.83 | SYK (0.37) | SYKBTKJAK3EGFRLCK | |
| SCHEMBL3360354 | 0.83 | MAP4K1 (0.41) | SYKBRD4BTKJAK3EGFR | |
| SCHEMBL3359270 | 0.82 | SYK (0.41) | SYKBTKJAK3EGFRLCK | |
| SCHEMBL3362595 | 0.80 | ZAP70 (0.48) | SYKBTKJAK3EGFRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |