Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 14/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361735 | 0.85 | SYK (0.40) | ZAP70CYP11B2CYP11B1SYKJAK3 | |
| SCHEMBL3359391 | 0.85 | ZAP70 (0.44) | ZAP70CYP11B2SYKJAK3BTK | |
| SCHEMBL1159575 | 0.85 | ZAP70 (0.49) | ZAP70SYKBTK | |
| SCHEMBL3362595 | 0.84 | ZAP70 (0.48) | ZAP70CYP11B2CYP11B1SYKJAK3 | |
| SCHEMBL3358634 | 0.84 | ZAP70 (0.49) | ZAP70JAK3BTKEGFRLCK | |
| SCHEMBL3359270 | 0.83 | SYK (0.41) | ZAP70CYP11B2CYP11B1SYKJAK3 | |
| SCHEMBL3360354 | 0.81 | MAP4K1 (0.41) | ZAP70CYP11B2CYP11B1SYKJAK3 | |
| SCHEMBL3362166 | 0.81 | ZAP70 (0.49) | ZAP70SYKJAK3BTKEGFR | |
| SCHEMBL3358971 | 0.80 | ZAP70 (0.47) | ZAP70JAK3 | |
| SCHEMBL3360902 | 0.80 | SYK (0.39) | ZAP70CYP11B2CYP11B1SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |