Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 5/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364042 | 0.88 | DPP4 (0.44) | LMNANPSR1HSD17B10HPGDTSHR | |
| SCHEMBL3363284 | 0.88 | DPP4 (0.41) | LMNANPSR1HPGDTSHRABCB1 | |
| SCHEMBL8360547 | 0.86 | LMNA (0.50) | LMNANPSR1HSD17B10HPGDTSHR | |
| SCHEMBL3359775 | 0.84 | DPP4 (0.59) | LMNANPSR1HSD17B10HPGDTSHR | |
| Hydrochloric Acid SCHEMBL3359772 | 0.83 | DPP4 (0.61) | LMNANPSR1HSD17B10HPGDTSHR | |
| SCHEMBL3361170 | 0.82 | RAB9A (0.44) | LMNANPSR1SMN1; SMN2GAAMAPT | |
| SCHEMBL3361923 | 0.79 | DPP4 (0.64) | LMNADPP4MAPT | |
| SCHEMBL3362364 | 0.76 | ABCB1 (0.40) | LMNAHSD17B10HPGDTSHRABCB1 | |
| SCHEMBL3361788 | 0.73 | DPP4 (0.61) | LMNANPSR1HSD17B10HPGDTSHR | |
| Hydrochloric Acid SCHEMBL3361781 | 0.73 | DPP4 (0.62) | LMNANPSR1HSD17B10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |