Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359356 | 0.78 | GRM4 (0.56) | GRM4KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6528085 | 0.75 | SYK (0.48) | HTTKDM4EALDH1A1LMNATSHR | |
| SCHEMBL28843686 | 0.71 | TLR8 (0.55) | GRM4CYP3A4TLR8NPC1RAB9A | |
| SCHEMBL3898712 | 0.70 | CYP3A4 (0.58) | GRM4CYP3A4TLR8LMNANPC1 | |
| SCHEMBL311094 | 0.70 | CYP3A4 (0.58) | GRM4CYP3A4TLR8KDM4ELMNA | |
| SCHEMBL30153587 | 0.70 | CYP3A4 (0.58) | GRM4CYP3A4TLR8KDM4ELMNA | |
| SCHEMBL29878333 | 0.70 | CYP3A4 (0.58) | GRM4CYP3A4TLR8LMNANPC1 | |
| SCHEMBL15778047 | 0.70 | KDM5A (0.64) | HTTNPC1RAB9AMAPTKDM5A | |
| SCHEMBL19968424 | 0.69 | CYP3A4 (0.57) | GRM4CYP3A4TLR8DYRK1AMAOA | |
| SCHEMBL23652014 | 0.67 | CYP3A4 (0.55) | GRM4CYP3A4TLR8DYRK1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |