Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 5/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361998 | 0.88 | ZAP70 (0.42) | ZAP70WEE1EGFR | |
| SCHEMBL3362577 | 0.82 | DYRK1A (0.48) | ZAP70WEE1AXLCAMK2DGSK3B | |
| SCHEMBL3359787 | 0.79 | SLC18A3 (0.36) | ZAP70 | |
| SCHEMBL3359006 | 0.78 | BTK (0.43) | ZAP70AXLEGFR | |
| SCHEMBL3360902 | 0.78 | SYK (0.39) | ZAP70EGFR | |
| SCHEMBL3362356 | 0.78 | BTK (0.38) | ZAP70WEE1 | |
| SCHEMBL3362321 | 0.78 | TGFBR1 (0.35) | ZAP70HRH3EGFR | |
| SCHEMBL3358792 | 0.77 | ZAP70 (0.42) | ZAP70WEE1EGFR | |
| SCHEMBL1048535 | 0.77 | ZAP70 (0.73) | ZAP70WEE1ADORA2AAXL | |
| SCHEMBL3359920 | 0.77 | IGF1R (0.39) | ZAP70CAMK2DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |