Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.96 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.96 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.96 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.96 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.96 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.96 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.96 |
| ▸ | HTR1A | P08908 | 2/20 | 0.96 |
| ▸ | TSHR | P16473 | 2/20 | 0.96 |
| ▸ | DRD1 | P21728 | 2/20 | 0.96 |
| ▸ | DRD3 | P35462 | 2/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | HTR7 | P34969 | 1/20 | 0.96 |
| ▸ | RAB9A | P51151 | 1/20 | 0.96 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.96 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.93 |
| ▸ | LMNA | P02545 | 3/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL289128 | 1.00 | HIF1A (0.96) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29382851 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29392606 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL4712 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL4711 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29374674 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL895602 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL412215 | 0.96 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL21829033 | 0.96 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL24655 | 0.96 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081187-B1 | LIQUID COMPOSITION COMPRISING IBUPROFEN AND PHENYLEPHRINE | NUTRA ESSENTIAL OTC S L (ES) | 2023-12-13 | — | — | EP | claimed |
| US-20230012144-A1 | LIQUID COMPOSITION COMPRISING IBUPROFEN AND PHENYLEPHRINE | NUTRA ESSENTIAL OTC, S.L. (ES) | 2023-01-12 | — | — | US | claimed |
| CN-114828829-A | Liquid composition comprising ibuprofen and phenylephrine | 纽特拉艾森索非处方药公司 | 2022-07-29 | — | — | CN | claimed |
| WO-2021130126-A1 | LIQUID COMPOSITION COMPRISING IBUPROFEN AND PHENYLEPHRINE | NUTRA ESSENTIAL OTC, S.L. (ES) | 2021-07-01 | — | — | WO | claimed |
| EP-2724720-B1 | Compositions of phenylephrine useful for treatment of respiratory illness | PROCTER & GAMBLE (US) | 2018-02-21 | — | — | EP | claimed |
| EP-2724720-A1 | Compositions of phenylephrine useful for treatment of respiratory illness | The Procter and Gamble Company (US) | 2014-04-30 | — | — | EP | claimed |
| EP-2032129-B1 | COMPOSITIONS OF PHENYLEPHRINE USEFUL FOR TREATMENT OF RESPIRATORY ILLNESS | PROCTER & GAMBLE (US) | 2014-01-29 | — | — | EP | claimed |
| EP-2046289-B1 | COMPOSITIONS AND KITS OF PHENYLEPHRINE | PROCTER & GAMBLE (US) | 2014-01-29 | — | — | EP | claimed |
| US-8518439-B2 | Liquid therapeutic composition | NOVARTIS AG (CH) | 2013-08-27 | — | — | US | claimed |
| US-20100136107-A1 | Liquid Therapeutic Composition | NOVARTIS AG (CH) | 2010-06-03 | — | — | US | claimed |
| EP-4081187-B1 | LIQUID COMPOSITION COMPRISING IBUPROFEN AND PHENYLEPHRINE | NUTRA ESSENTIAL OTC S L (ES) | 2023-12-13 | — | — | EP | disclosed |
| EP-3582751-B1 | STRUCTURED ORODISPERSIBLE FILMS | LTS LOHMANN THERAPIE SYSTEME AG (DE) | 2023-09-06 | — | — | EP | disclosed |
| US-20230012144-A1 | LIQUID COMPOSITION COMPRISING IBUPROFEN AND PHENYLEPHRINE | NUTRA ESSENTIAL OTC, S.L. (ES) | 2023-01-12 | — | — | US | disclosed |
| CN-114828829-A | Liquid composition comprising ibuprofen and phenylephrine | 纽特拉艾森索非处方药公司 | 2022-07-29 | — | — | CN | disclosed |
| US-20220152016-A1 | Compositions And Kits Useful For Treatment Of Respiratory Illness | PROCTER & GAMBLE (US) | 2022-05-19 | — | — | US | disclosed |
| US-20070254027-A1 | Compositions and methods useful for treatment of respiratory illness | THE PROCTER & GAMBLE COMPANY (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007122580-A2 | COMPOSITIONS OF PHENYLEPHRINE USEFUL FOR TREATMENT OF RESPIRATORY ILLNESS | THE PROCTER & GAMBLE COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007122581-A2 | COMPOSITIONS AND KITS OF PHENYLEPHRINE | THE PROCTER & GAMBLE COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |
| US-20070249727-A1 | Compositions and kits useful for treatment of respiratory illness | THE PROCTOR & GAMBLE COMPANY (US) | 2007-10-25 | — | — | US | disclosed |
| US-20070249566-A1 | Compositions and methods useful for treatment of respiratory illness | THE PROCTER & GAMBLE COMPANY | 2007-10-25 | — | — | US | disclosed |