Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 4/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 3/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 3/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR7 | P34969 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL4711 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29382851 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL895602 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL4712 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29392606 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL24655 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL10953364 | 0.98 | HIF1A (0.96) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL21829033 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL412215 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL24654 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12324845-B2 | Ligands for imaging cardiac innervation | LANTHEUS MEDICAL IMAGING, INC. (US) | 2025-06-10 | — | — | US | disclosed |
| US-20250161500-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | LANTHEUS MEDICAL IMAGING, INC. (US) | 2025-05-22 | — | — | US | disclosed |
| US-20220288243-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | LANTHEUS MEDICAL IMAGING, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| US-11241509-B2 | Ligands for imaging cardiac innervation | LANTHEUS MEDICAL IMAGING, INC. (US) | 2022-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220288243-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | TNNT2, PNMT, TNNC1 | ADRA1A 17/4885ADRA1B 15/4885ADRA1D 24/4885 |
| US-11241509-B2 | Ligands for imaging cardiac innervation | TNNT2, PNMT, TNNC1 | ADRA1A 19/4885ADRA1B 15/4885ADRA1D 27/4885 |
| US-20250161500-A1 | LIGANDS FOR IMAGING CARDIAC INNERVATION | TNNT2, PNMT, TNNC1 | ADRA1A 17/4885ADRA1B 15/4885ADRA1D 24/4885 |
| US-12324845-B2 | Ligands for imaging cardiac innervation | CHRNB4, RXFP4, RXFP3 | ADRA1A 158/4885ADRA1B 118/4885ADRA1D 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.