Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 1.00 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 4/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 3/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 3/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | DRD1 | P21728 | 2/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HTR7 | P34969 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.96 |
| ▸ | LMNA | P02545 | 3/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylephrine SCHEMBL4711 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29382851 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL895602 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29392606 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL29374674 | 1.00 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL24655 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL10953364 | 0.98 | HIF1A (0.96) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL21829033 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL412215 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 | |
| Phenylephrine SCHEMBL24654 | 0.98 | HIF1A (1.00) | HIF1AADRA2AADRA2BADRA2CADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 40590 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075410-A | Dry powder composition for intranasal delivery | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| US-20260137558-A1 | OPHTHALMIC DEVICE | Able Tx Ltd. (IL) | 2026-05-21 | — | — | US | claimed |
| US-12629422-B2 | Agave syrup formulation or suspension for active pharmaceutical agents | GENEXA INC. (US) | 2026-05-19 | — | — | US | claimed |
| US-20260130870-A1 | PHENYLEPHRINE LIQUID FORMULATIONS | FRESENIUS KABI AUSTRIA GMBH (AT) | 2026-05-14 | — | — | US | claimed |
| EP-4734952-A1 | ORAL TABLET WITH IMPROVED UNIFORMITY OF CONTENT OF ACTIVES | Fertin Pharma A/S (DK) | 2026-05-06 | — | — | EP | claimed |
| EP-4736841-A1 | A MUCOADHESIVE LAYER FOR BUCCAL ADMINISTRATION OF AN ACTIVE PHARMACEUTICAL INGREDIENT | IQ medical GmbH (DE) | 2026-05-06 | — | — | EP | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| EP-4731194-A1 | MATERIALS AND METHODS FOR MITIGATING THE PRESENCE OF NITROSAMINES IN PACKAGING USING AN ACTIVE AGENT | CSP Technologies, Inc. (US) | 2026-04-29 | — | — | EP | claimed |
| US-20260108531-A1 | Methods of Treating Hypogonadism with Transnasal Testosterone Bio-adhesive Gel Formulations in Males with Allergic Rhinitis and Methods for Preventing an Allergic Rhinitis Event | ACERUS BIOPHARMA INC (CA) | 2026-04-23 | — | — | US | claimed |
| US-4125186-A | Pharmaceutical delivery system | WARNER-LAMBERT COMPANY (US) | 1978-11-14 | — | — | US | claimed |
| US-4108973-A | OXIDATION | HOFFMANN-LA ROCHE INC. (US) | 1978-08-22 | — | — | US | claimed |
| US-4100271-A | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes | COOPER LABORATORIES, INC. (US) | 1978-07-11 | — | — | US | claimed |
| US-4014335-A | Ocular drug delivery device | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4014334-A | Laminated osmotic system for dispensing beneficial agent | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4008719-A | Osmotic system having laminar arrangement for programming delivery of active agent | ALZA CORPORATION (US) | 1977-02-22 | — | — | US | claimed |
| US-4001388-A | POLYESTERS | ALZA CORPORATION (US) | 1977-01-04 | — | — | US | claimed |
| US-3968147-A | COORDINATION CATALYST | MONSANTO COMPANY (US) | 1976-07-06 | — | — | US | claimed |
| US-3966749-A | Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof | INTERX RESEARCH CORPORATION (US) | 1976-06-29 | — | — | US | claimed |
| US-3933999-A | 1-METHYL-2-(2-(ALPHA-METHYL-P -CHLORODIPHENYLMETHOXY)ETHYL)PYRROLIDONE, RHINITIS, VASOCONSTRICTOR | SANDOZ LTD., (SANDOZ AG) (CH) | 1976-01-20 | — | — | US | claimed |