Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 6/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 7/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 5/20 | 0.34 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3358701 | 0.90 | ZAP70 (0.47) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3359243 | 0.86 | ZAP70 (0.38) | ZAP70SYKJAK3EGFRLCK | |
| SCHEMBL3358634 | 0.82 | ZAP70 (0.49) | ZAP70JAK3EGFRLCKBTK | |
| SCHEMBL3362166 | 0.81 | ZAP70 (0.49) | ZAP70SYKJAK3EGFRLCK | |
| SCHEMBL3356474 | 0.81 | ZAP70 (0.37) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL3362358 | 0.80 | ZAP70 (0.45) | ZAP70SYKTLR9TLR8TLR7 | |
| SCHEMBL27805983 | 0.80 | ZAP70 (0.44) | ZAP70JAK3EGFRLCKBTK | |
| SCHEMBL1159575 | 0.80 | ZAP70 (0.49) | ZAP70SYKBTK | |
| SCHEMBL1048199 | 0.80 | ZAP70 (0.73) | ZAP70SYK | |
| SCHEMBL3359436 | 0.79 | ZAP70 (0.48) | ZAP70SYKEGFRTLR9TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |