Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 14/20 | 0.37 |
| ▸ | BTK | Q06187 | 11/20 | 0.37 |
| ▸ | LCK | P06239 | 10/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158304 | 0.93 | ZAP70 (0.44) | ZAP70JAK3LCK | |
| SCHEMBL3360152 | 0.88 | ZAP70 (0.64) | ZAP70 | |
| SCHEMBL3360188 | 0.85 | ZAP70 (0.48) | ZAP70JAK3BTKLCKEGFR | |
| SCHEMBL1159575 | 0.85 | ZAP70 (0.49) | ZAP70BTK | |
| SCHEMBL3362166 | 0.84 | ZAP70 (0.49) | ZAP70JAK3BTKLCKEGFR | |
| SCHEMBL3360737 | 0.84 | ZAP70 (0.46) | ZAP70JAK3BTKLCKEGFR | |
| SCHEMBL3362358 | 0.84 | ZAP70 (0.45) | ZAP70 | |
| SCHEMBL3362971 | 0.83 | JAK2 (0.38) | ZAP70JAK3BTKLCKEGFR | |
| SCHEMBL3362917 | 0.82 | ZAP70 (0.45) | ZAP70JAK3BTKLCKEGFR | |
| SCHEMBL3362296 | 0.81 | ZAP70 (0.49) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |