Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359436 | 0.88 | ZAP70 (0.48) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3362708 | 0.87 | ZAP70 (0.49) | ZAP70SYKPDE10AWNT3ACSF1R | |
| SCHEMBL3363030 | 0.83 | ZAP70 (0.39) | ZAP70SYKPDE10AALKINSR | |
| SCHEMBL3362917 | 0.81 | ZAP70 (0.45) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL27826506 | 0.80 | ZAP70 (0.35) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL1048656 | 0.80 | ZAP70 (0.61) | ZAP70TLR9TLR8TLR7 | |
| SCHEMBL3358701 | 0.78 | ZAP70 (0.47) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3359512 | 0.78 | ZAP70 (0.51) | ZAP70SYKKCNH2KDR | |
| SCHEMBL3357306 | 0.77 | ZAP70 (0.37) | ZAP70TLR9TLR8TLR7SYK | |
| SCHEMBL3363341 | 0.77 | SYK (0.41) | ZAP70SYKWNT3APIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |