Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | CA12 | O43570 | 3/20 | 0.64 |
| ▸ | CA9 | Q16790 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.64 |
| ▸ | CA6 | P23280 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL27304495 | 0.93 | KDM4E (0.60) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL294304 | 0.91 | ALDH1A1 (0.72) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL8621859 | 0.91 | ALDH1A1 (0.72) | ALDH1A1KDM4ECA12CA9HPGD | |
| Dodecane SCHEMBL6692297 | 0.89 | ALDH1A1 (0.69) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL28366261 | 0.89 | ALDH1A1 (0.69) | ALDH1A1KDM4ECA12CA9HPGD | |
| Hexadecane SCHEMBL28225619 | 0.89 | ALDH1A1 (0.69) | ALDH1A1KDM4ECA12CA9HPGD | |
| Phthalic Acid SCHEMBL27708614 | 0.89 | ALDH1A1 (0.58) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL1003308 | 0.87 | ALDH1A1 (0.78) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL28084608 | 0.86 | ALDH1A1 (0.64) | ALDH1A1KDM4ECA12CA9HPGD | |
| Salicylic Acid SCHEMBL15623328 | 0.85 | ALDH1A1 (0.75) | ALDH1A1KDM4ECA12CA9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103403061-A | Alkylene oxide polymerization using a double metal cyanide catalyst complex and a magnesium, group 3-group 15 metal or lanthanide series metal compound | DOW GLOBAL TECHNOLOGIES INC | 2013-11-20 | — | — | CN | disclosed |
| US-7666566-B2 | Electrophotographic toner and method of preparing the toner | RICOH COMPANY, LTD. (JP) | 2010-02-23 | — | — | US | disclosed |
| CN-100351275-C | Morphology controlled olefin polymerization process | DOW GLOBAL TECHNOLOGIES INC (US) | 2007-11-28 | — | — | CN | disclosed |
| CN-1764674-A | Morphology controlled olefin polymerization process | DOW GLOBAL TECHNOLOGIES INC (US) | 2006-04-26 | — | — | CN | disclosed |
| US-20050196691-A1 | Electrophotographic toner and method of preparing the toner | RICOH COMPANY, LTD. (JP) | 2005-09-08 | — | — | US | disclosed |
| CN-1347755-A | Multi-metallic oxide catalyst accelerated with Zn and/or Ga | ROHM & HAAS (US) | 2002-05-08 | — | — | CN | disclosed |
| CN-88101652-A | imaging system with combination coating | — | 1988-12-07 | — | — | CN | disclosed |