Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS1 | P56192 | 5/20 | 0.50 |
| ▸ | CRHR1 | P34998 | 11/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3367005 | 0.88 | CRHR1 (0.45) | MARS1CRHR1CNR1MAPT | |
| SCHEMBL3363564 | 0.88 | CRHR1 (0.44) | MARS1CRHR1TSHRCNR1MAPT | |
| SCHEMBL3367536 | 0.84 | CRHR1 (0.49) | MARS1CRHR1CNR1 | |
| SCHEMBL3364763 | 0.80 | CRHR1 (0.44) | MARS1CRHR1CNR1MAPT | |
| SCHEMBL8296178 | 0.80 | CRHR1 (0.49) | MARS1CRHR1 | |
| SCHEMBL3363623 | 0.79 | CRHR1 (0.42) | MARS1CRHR1CNR1MAPT | |
| SCHEMBL14231150 | 0.78 | CRHR1 (0.38) | CRHR1TSHRMAPT | |
| SCHEMBL14206630 | 0.77 | CRHR1 (0.49) | CRHR1CNR1MAPT | |
| SCHEMBL3364027 | 0.76 | ALPL (0.47) | CRHR1CNR1 | |
| Trifluoroacetic Acid SCHEMBL4699530 | 0.76 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-B1 | GABANERGIC MODULATORS | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | claimed |
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |