Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 5/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.43 |
| ▸ | PRKACA | P17612 | 4/20 | 0.43 |
| ▸ | GSK3A | P49840 | 4/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | PRKX | P51817 | 3/20 | 0.43 |
| ▸ | PRKCG | P05129 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MARK3 | P27448 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3366022 | 0.99 | DPP4 (0.55) | DPP4ROCK1PRKACAGSK3AGSK3B | |
| SCHEMBL3363205 | 0.76 | DPP4 (0.56) | DPP4MAPK1HPGD | |
| SCHEMBL3365084 | 0.75 | DPP4 (0.57) | DPP4RPS6KB1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3366027 | 0.75 | DPP4 (0.56) | DPP4MAPK1HPGD | |
| SCHEMBL3361560 | 0.75 | DPP4 (0.74) | DPP4 | |
| SCHEMBL7716544 | 0.75 | DPP4 (0.65) | DPP4MAPK1 | |
| Hydrochloric Acid SCHEMBL3366032 | 0.75 | DPP4 (0.58) | DPP4RPS6KB1ALDH1A1 | |
| SCHEMBL3362414 | 0.74 | DPP4 (0.61) | DPP4ROCK1ROCK2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3361903 | 0.74 | DPP4 (0.62) | DPP4ROCK1ROCK2ALDH1A1HPGD | |
| SCHEMBL3362219 | 0.70 | GAA (0.49) | DPP4ROCK1MAPK1ROCK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | claimed |
| US-7732446-B1 | Dipeptidyl peptidase inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-08 | — | — | US | disclosed |