Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1158187 | 0.89 | SYK (0.40) | ZAP70APPCSF1RCDK4CDK6 | |
| SCHEMBL3359095 | 0.89 | ZAP70 (0.45) | ZAP70PTK2SYK | |
| SCHEMBL3360732 | 0.88 | CSF1R (0.38) | APPCSF1RCDK4CDK6NOTUM | |
| SCHEMBL28790593 | 0.79 | ZAP70 (0.35) | ZAP70APPCSF1RCDK4CDK6 | |
| SCHEMBL1049720 | 0.79 | ZAP70 (0.61) | ZAP70APPCSF1RCDK4CDK6 | |
| SCHEMBL3361975 | 0.78 | KDR (0.38) | ZAP70PTK2SYK | |
| SCHEMBL3361858 | 0.78 | ZAP70 (0.47) | ZAP70APPCSF1RCDK4CDK6 | |
| SCHEMBL3359250 | 0.77 | ZAP70 (0.53) | ZAP70SYK | |
| SCHEMBL3360152 | 0.76 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL3359784 | 0.75 | ZAP70 (0.51) | ZAP70ALKSYKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |