Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.47 |
| ▸ | SYK | P43405 | 10/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 4/20 | 0.39 |
| ▸ | CDK4 | P11802 | 4/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359250 | 0.91 | ZAP70 (0.53) | ZAP70SYKJAK2 | |
| SCHEMBL3359095 | 0.90 | ZAP70 (0.45) | ZAP70SYKJAK2ACVR1CCNA2 | |
| SCHEMBL3360818 | 0.89 | SYK (0.42) | ZAP70SYKJAK2ACVR1CSF1R | |
| SCHEMBL1158187 | 0.88 | SYK (0.40) | ZAP70SYKJAK2CSF1RCDK4 | |
| SCHEMBL3362708 | 0.86 | ZAP70 (0.49) | ZAP70SYKCSF1RCDK4CDK6 | |
| SCHEMBL3362654 | 0.85 | ZAP70 (0.39) | ZAP70SYK | |
| SCHEMBL3360152 | 0.83 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL3359784 | 0.82 | ZAP70 (0.51) | ZAP70SYK | |
| SCHEMBL3359512 | 0.82 | ZAP70 (0.51) | ZAP70SYK | |
| SCHEMBL3361376 | 0.81 | ZAP70 (0.42) | ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | claimed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | claimed |