Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | SYK | P43405 | 7/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3361858 | 0.90 | ZAP70 (0.47) | ZAP70CCNA2CDK2SYKJAK2 | |
| SCHEMBL3361975 | 0.89 | KDR (0.38) | ZAP70KDRCCNA2CDK2CCNA1 | |
| SCHEMBL3363322 | 0.89 | ZAP70 (0.38) | ZAP70SYKPTK2 | |
| SCHEMBL3359250 | 0.89 | ZAP70 (0.53) | ZAP70SYKJAK2ABL1 | |
| SCHEMBL3362708 | 0.85 | ZAP70 (0.49) | ZAP70KDRCCNA2CDK2SYK | |
| SCHEMBL3360152 | 0.81 | ZAP70 (0.64) | ZAP70SYKABL1 | |
| SCHEMBL3359784 | 0.80 | ZAP70 (0.51) | ZAP70SYKABL1 | |
| SCHEMBL3359512 | 0.80 | ZAP70 (0.51) | ZAP70KDRSYK | |
| SCHEMBL3362654 | 0.79 | ZAP70 (0.39) | ZAP70SYK | |
| SCHEMBL3360818 | 0.79 | SYK (0.42) | ZAP70CCNA2CDK2SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238137-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009097287-A1 | COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-06 | — | — | WO | disclosed |