Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chloroform. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL8829928 | 1.00 | — | — | |
| Chloroform SCHEMBL27532873 | 1.00 | LMNA (0.58) | LMNACA1CA2CA9ALDH1A1 | |
| Chloroform SCHEMBL2360396 | 0.95 | — | — | |
| Chloroform SCHEMBL3804250 | 0.95 | — | — | |
| Chloroform SCHEMBL27824229 | 0.84 | — | — | |
| Oxalic Acid SCHEMBL28297039 | 0.84 | LMNA (0.54) | LMNACA1CA2CA9ALDH1A1 | |
| Bicarbonate SCHEMBL29569190 | 0.82 | — | — | |
| Chloroform SCHEMBL28055651 | 0.82 | — | — | |
| Chloroform SCHEMBL28940869 | 0.80 | — | — | |
| Acetic Acid SCHEMBL694363 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112159402-B | Preparation method of rivaroxaban | 南京法恩化学有限公司 | 2022-04-05 | — | — | CN | claimed |
| CN-112159402-A | Preparation method of rivaroxaban | 南京法恩化学有限公司 | 2021-01-01 | — | — | CN | claimed |
| CN-114149401-B | Synthesis method of vinyl ethylene carbonate | 苏州华一新能源科技股份有限公司 | 2023-03-24 | — | — | CN | disclosed |
| CN-112159402-B | Preparation method of rivaroxaban | 南京法恩化学有限公司 | 2022-04-05 | — | — | CN | disclosed |
| CN-114149401-A | Synthesis method of vinyl ethylene carbonate | 苏州华一新能源科技股份有限公司 | 2022-03-08 | — | — | CN | disclosed |
| CN-107880877-B | Preparation method and application of monodisperse polymer fluorescent microspheres | 上海艾瑞德生物科技有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-112159402-A | Preparation method of rivaroxaban | 南京法恩化学有限公司 | 2021-01-01 | — | — | CN | disclosed |
| US-7691931-B2 | Organic-inorganic hybrid material and method of preparing the organic-inorganic hybrid material, and electrophotographic photoreceptor, process cartridge, image forming apparatus and image forming method using the organic-inorganic hybrid material | RICOH COMPANY LTD. (JP) | 2010-04-06 | — | — | US | disclosed |
| US-20060122303-A1 | Organic-inorganic hybrid material and method of preparing the organic-inorganic hybrid material, and electrophotographic photoreceptor, process cartridge, image forming apparatus and image forming method using the organic-inorganic hybrid material | RICOH COMPANY, LTD. (JP) | 2006-06-08 | — | — | US | disclosed |
| US-6486293-B1 | Electrophotographic photoconductor and method of producing aromatic polycarbonate resin for use in the photoconductor | RICOH COMPANY, LTD. (JP) | 2002-11-26 | — | — | US | disclosed |
| US-6187492-B1 | ELECTROCONDUCTIVE SUPPORT COATED WITH A PHOTOCONDUCTIVE CHARGE TRANSPORT LAYER OF SOLUTION POLYMERIZED COPOLYCARBONATE HAVING TRIARYLAMINE DIPHENOL UNITS AND DIHYDROXY SUBSTITUTED ARYL BENZOATE UNITS; PHOTOSENSITIVITY | RICOH COMPANY, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |