Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thymine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.79 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | DPYD | Q12882 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HBB | P68871 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KLF10 | Q13118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymine SCHEMBL4349014 | 1.00 | ATAD2 (0.79) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL188134 | 1.00 | ATAD2 (0.79) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL1452487 | 1.00 | ATAD2 (0.79) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL28575361 | 0.98 | ATAD2 (0.76) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL28570793 | 0.98 | ATAD2 (0.76) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL6911382 | 0.92 | ATAD2 (0.73) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL6911389 | 0.90 | ATAD2 (0.76) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL23794979 | 0.89 | ATAD2 (0.91) | ATAD2GAADPYDLMNAMAPT | |
| Thymine SCHEMBL5235 | 0.89 | — | — | |
| Thymine SCHEMBL15323914 | 0.89 | ATAD2 (1.00) | ATAD2GAADPYDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921532-B2 | Phospholink nucleotides for sequencing applications | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2014-12-30 | — | — | US | disclosed |
| US-20140065607-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-8580539-B2 | Phospholink nucleotides for sequencing applications | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130122490-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2013-05-16 | — | — | US | disclosed |
| US-8367813-B2 | Phospholink nucleotides for sequencing applications | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100167299-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| WO-2010057185-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2010-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100167299-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | POLN, DTYMK, POLRMT | ATAD2 2293/4885GAA 3352/4885DPYD 39/4885 |
| US-20140065607-A1 | PHOSPHOLINK NUCLEOTIDES FOR SEQUENCING APPLICATIONS | POLN, DTYMK, POLRMT | ATAD2 2255/4885GAA 3408/4885DPYD 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.