Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LPAR2 | Q9HBW0 | 4/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3364505 | 0.90 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL14681047 | 0.89 | MEN1 (0.45) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL4377856 | 0.89 | MEN1 (0.62) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL9889761 | 0.88 | MEN1 (0.41) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| Bromide SCHEMBL31354579 | 0.88 | MEN1 (0.44) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL29201320 | 0.86 | MEN1 (0.40) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL14681038 | 0.85 | CYP1A2 (0.43) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL12905322 | 0.85 | MEN1 (0.43) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL22953516 | 0.84 | MEN1 (0.50) | MEN1KMT2ATP53CYP1A2CYP2D6 | |
| SCHEMBL22953510 | 0.84 | MEN1 (0.50) | MEN1KMT2ATP53CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7663797-B2 | Multicolor display element | RICOH COMPANY, LTD. (JP) | 2010-02-16 | — | — | US | disclosed |
| US-7333259-B2 | Multicolor display element | RICOH COMPANY, LTD. (JP) | 2008-02-19 | — | — | US | disclosed |
| US-20080013152-A1 | MULTICOLOR DISPLAY ELEMENT | HIRANO SHIGENOBU | 2008-01-17 | — | — | US | disclosed |
| US-20070024948-A1 | Multicolor display element | RICOH COMPANY, LTD. (JP) | 2007-02-01 | — | — | US | disclosed |