Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22953517 | 0.94 | MEN1 (0.68) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22953511 | 0.94 | MEN1 (0.68) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22953515 | 0.94 | MEN1 (0.68) | MEN1KMT2AMAPTTP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL3364608 | 0.89 | MEN1 (0.46) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL14681047 | 0.88 | MEN1 (0.45) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22953513 | 0.87 | MEN1 (0.58) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22931361 | 0.87 | MEN1 (0.58) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22953516 | 0.86 | MEN1 (0.50) | MEN1KMT2AMAPTTP53CYP1A2 | |
| SCHEMBL22953510 | 0.86 | MEN1 (0.50) | MEN1KMT2AMAPTTP53CYP1A2 | |
| Bromide SCHEMBL31354579 | 0.86 | MEN1 (0.44) | MEN1KMT2AMAPTTP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7489432-B2 | Electrochromic display device and display apparatus | RICOH COMPANY, LTD. (JP) | 2009-02-10 | — | — | US | disclosed |
| US-20060215250-A1 | Electrochromic display device and display apparatus | RICOH COMPANY, LTD. (JP) | 2006-09-28 | — | — | US | disclosed |