SCHEMBL3364624

SCHEMBL3364624

O=C(c1ccc(F)cc1)C(Br)Br

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 5/20 0.61
CES2 O00748 1/20 0.54
CES1 P23141 1/20 0.54
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
PTPN1 P18031 1/20 0.50
BCL2L1 Q07817 1/20 0.46
BAD Q92934 1/20 0.46
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
LTA4H P09960 1/20 0.43
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
ALPG P10696 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A3 Q01959 1/20 0.41
TNFRSF1A P19438 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9644843 0.87 GSK3B (0.76) GSK3BCES2CES1CA1CA2
SCHEMBL8554736 0.84 CES2 (0.52) GSK3BCES2CES1CA1CA2
SCHEMBL1938267 0.82 CES2 (0.50) GSK3BCES2CES1CA1CA2
SCHEMBL28075917 0.82 CES2 (0.50) GSK3BCES2CES1CA1CA2
SCHEMBL2534850 0.80 CES2 (0.48) GSK3BCES2CES1CA1CA2
SCHEMBL2962521 0.78 GSK3B (0.64) GSK3BCES2CES1CA1CA2
SCHEMBL31191256 0.78 CES2 (0.64) CES2CES1CA1CA2PTPN1
SCHEMBL835861 0.78 CES2 (0.56) CES2CES1CA1CA2PTPN1
SCHEMBL2096724 0.78 GSK3B (0.64) GSK3BCES2CES1CA1CA2
SCHEMBL7350941 0.78 GSK3B (0.64) GSK3BCES2CA1CA2PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-62185002-A None JP disclosed
CN-113292552-B Benzo five-membered ring aza derivative containing benzophenone group and preparation method and application thereof 广东工业大学 2022-02-08 CN disclosed
CN-113292552-A Benzo five-membered ring aza derivative containing benzophenone group and preparation method and application thereof 广东工业大学 2021-08-24 CN disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
JP-S62185002-A SLIME-CONTROLLING AGENT FOR PAPER-MAKING PAAMAKEMU ASIA:KK 1987-08-13 JP disclosed