Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068122 | 0.83 | MEN1 (0.44) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL336855 | 0.81 | MEN1 (0.56) | ALDH1A1SMN1; SMN2RAB9ANPSR1TYMS | |
| SCHEMBL3974904 | 0.71 | TNF (0.77) | KDM4EALDH1A1SMN1; SMN2HPGDTP53 | |
| SCHEMBL13200995 | 0.71 | SMN1; SMN2 (0.47) | KDM4EALDH1A1SMN1; SMN2TP53MDM2 | |
| SCHEMBL31447620 | 0.71 | DPP4 (0.41) | KDM4EALDH1A1SMN1; SMN2RAB9ACDK9 | |
| SCHEMBL7498482 | 0.70 | GALR3 (0.50) | GALR3NR2F2RAB9ATNF | |
| SCHEMBL22533423 | 0.69 | DCTPP1 (0.55) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL2952808 | 0.66 | DYRK3 (0.33) | DYRK1ADYRK2 | |
| SCHEMBL1923869 | 0.66 | NPC1 (0.49) | KDM4EALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL7932316 | 0.64 | GALR3 (0.62) | KDM4ESMN1; SMN2TP53GALR3NR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8097727-B2 | N,N′-diphenylurea derivatives which are suitable as kinase inhibitors | MERCK PATENT GMBH (DE) | 2012-01-17 | — | — | US | disclosed |
| US-20080114026-A1 | N,N'-Diphenylurea Derivatives Which are Suitable as Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-05-15 | — | — | US | disclosed |
| EP-1799679-B1 | N,N'-DITHENYLUREA DERIVATIVES SUITABLE AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2008-01-23 | — | — | EP | disclosed |
| EP-1799679-A1 | N,N'-DITHENYLUREA DERIVATIVES USED IN THE FORM OF KINASE INHIBITORS | Merck Patent GmbH (DE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006040039-A1 | N,N'-DITHENYLUREA DERIVATIVES USED IN THE FORM OF KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080114026-A1 | N,N'-Diphenylurea Derivatives Which are Suitable as Kinase Inhibitors | TIE1, RET, KDR | KDM4E 773/4885ALDH1A1 1708/4885SMN1; SMN2 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.