Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362428 | 0.89 | PGR (0.51) | L3MBTL1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL3365026 | 0.89 | L3MBTL1 (0.47) | L3MBTL1TDP1MEN1KMT2AALDH1A1 | |
| SCHEMBL3369004 | 0.89 | CACNA1H (0.47) | NPSR1L3MBTL1TDP1CACNA1HCACNA1B | |
| SCHEMBL3368579 | 0.88 | FFAR1 (0.54) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3365676 | 0.88 | FFAR1 (0.54) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3362825 | 0.88 | FFAR1 (0.54) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3368425 | 0.86 | KDM4E (0.60) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3368655 | 0.85 | FFAR1 (0.51) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3367350 | 0.84 | FFAR1 (0.53) | FFAR1NPSR1L3MBTL1MAPTTDP1 | |
| SCHEMBL3368340 | 0.84 | FFAR1 (0.53) | FFAR1NPSR1L3MBTL1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303503-B1 | ANILINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-01-27 | — | — | EP | disclosed |
| US-6683201-B2 | FOR THERAPY AND PROPHYLAXIS OF HYPERCHOLESTEROLEMIA, HYPERLIPEMIA, ARTERIOSCLEROSIS, VASCULAR DISEASES, MYCOSES, PARASITE INFECTIONS, GALLSTONES, TUMORS AND/OR HYPERPROLIFERATIVE DISORDERS, DIABETES | HOFFMANN-LA ROCHE INC. | 2004-01-27 | — | — | US | disclosed |
| EP-1303503-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-23 | — | — | EP | disclosed |
| WO-2002006189-A2 | ANILINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-24 | — | — | WO | disclosed |