Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.46 |
| ▸ | HMGCR | P04035 | 2/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.41 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.35 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4795608 | 0.98 | SLC22A6 (0.44) | SLC22A6HMGCRMETAP1GPR84GABRR1 | |
| SCHEMBL6565930 | 0.78 | MAPT (0.42) | METAP1ALDH1A1MAPTKDM5AKDM4C | |
| SCHEMBL6517422 | 0.78 | METAP1 (0.49) | METAP1ALDH1A1KDM5AKDM4CPHF8 | |
| SCHEMBL7429602 | 0.78 | METAP1 (0.50) | METAP1 | |
| SCHEMBL1365294 | 0.78 | ALDH1A1 (0.48) | SLC22A6METAP1GABRR1LMNAALDH1A1 | |
| SCHEMBL26138089 | 0.78 | SLC22A6 (0.75) | SLC22A6GPR84GABRR1LMNAMAPT | |
| SCHEMBL1162229 | 0.77 | METAP1 (0.51) | METAP1LMNAALDH1A1KDM5AKDM4C | |
| SCHEMBL18939426 | 0.77 | METAP1 (0.51) | METAP1LMNAALDH1A1KDM5AKDM4C | |
| SCHEMBL27534064 | 0.77 | FOLH1 (0.48) | METAP1LMNAALDH1A1KDM5AKDM4C | |
| SCHEMBL10338247 | 0.77 | HMGCR (0.45) | SLC22A6HMGCRGPR84GABRR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776349-B1 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-06 | — | — | EP | claimed |