Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.48 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | CCNC | P24863 | 2/20 | 0.44 |
| ▸ | CDK8 | P49336 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366195 | 0.90 | HCRTR1 (0.56) | HSD11B1HCRTR1HCRTR2EIF4A3ALDH1A1 | |
| SCHEMBL3370658 | 0.87 | HSD11B1 (0.49) | HSD11B1HCRTR1HCRTR2EIF4A3ALDH1A1 | |
| SCHEMBL3366727 | 0.86 | MAPT (0.49) | HSD11B1HCRTR1HCRTR2ALDH1A1ALOX15B | |
| SCHEMBL3366901 | 0.84 | HCRTR1 (0.61) | HSD11B1HCRTR1HCRTR2RAB9A | |
| SCHEMBL3370346 | 0.83 | HCRTR2 (0.52) | HSD11B1HCRTR1HCRTR2EIF4A3ALDH1A1 | |
| SCHEMBL3370671 | 0.83 | HCRTR2 (0.49) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL3368653 | 0.82 | ROCK2 (0.54) | HSD11B1HCRTR1HCRTR2SMN1; SMN2 | |
| SCHEMBL3369372 | 0.80 | HSD11B1 (0.51) | HSD11B1HCRTR1HCRTR2ALDH1A1ALOX15B | |
| SCHEMBL3367057 | 0.80 | HCRTR1 (0.65) | HCRTR1HCRTR2ALDH1A1RAB9A | |
| SCHEMBL3366997 | 0.80 | LMNA (0.48) | HSD11B1HCRTR1HCRTR2ALDH1A1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532141-B1 | 2-PYRROLIDIN-2-YL- [1,3,4]-OXADIAZOLE DERIVATIVES AND THE USE OF THE SAME AS ANTIDEPRESSANTS | GRUENENTHAL GMBH (DE) | 2010-10-13 | — | — | EP | disclosed |