Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.62 |
| ▸ | MAOB | P27338 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366999 | 1.00 | MAOA (0.62) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL3367066 | 0.90 | TP53 (0.64) | MAOAMAOBPOLBTP53MAPT | |
| SCHEMBL3367069 | 0.90 | TP53 (0.64) | MAOAMAOBPOLBTP53MAPT | |
| SCHEMBL3367239 | 0.89 | MAOB (0.80) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL3367241 | 0.89 | MAOB (0.80) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL3364821 | 0.88 | MAOA (0.78) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL3366490 | 0.88 | MAOA (0.78) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL3366962 | 0.88 | MAOA (0.78) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL5569242 | 0.82 | MMP1 (0.53) | MAOAMAOBNPC1RAB9APOLB | |
| SCHEMBL5569247 | 0.82 | MMP1 (0.53) | MAOAMAOBNPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542970-B1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | HOFFMANN LA ROCHE (CH) | 2010-06-30 | — | — | EP | disclosed |
| US-7151111-B2 | 4-pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2006-12-19 | — | — | US | disclosed |
| EP-1542970-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116707-A1 | 4-Pyrrolidino-phenyl-benzyl ether derivatives | HOFFMANN-LA ROCHE INC. | 2004-06-17 | — | — | US | disclosed |
| WO-2004026825-A1 | PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2004-04-01 | — | — | WO | disclosed |